Ornella Cuomo Selected Research

Sodium-Calcium Exchanger

1/2020	Sumoylation of sodium/calcium exchanger in brain ischemia and ischemic preconditioning.
1/2018	Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia.
3/2016	NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum.
8/2015	Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.
5/2015	Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.
1/2013	Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.
1/2012	NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia.
1/2011	The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning.
11/2004	Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia.

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Ornella Cuomo Research Topics

Disease

16	Brain Ischemia (Cerebral Ischemia) 06/2022 - 11/2004
15	Stroke (Strokes) 06/2022 - 12/2007
10	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/2021 - 01/2013
7	Ischemia 06/2022 - 11/2004
5	Infarction (Infarctions) 06/2022 - 02/2008
3	Hypoxia (Hypoxemia) 01/2021 - 04/2016
3	Ischemic Stroke 01/2021 - 01/2013
2	Hemorrhage 01/2021 - 01/2013
2	Brain Injuries (Brain Injury) 01/2018 - 01/2013
2	Burns 01/2018 - 01/2015
2	Pressure Ulcer (Bedsore) 01/2018 - 01/2015
1	Hemorrhagic Stroke 01/2021
1	Brain Infarction 01/2021
1	Gliosis 12/2018
1	Inflammation (Inflammations) 01/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Neuroblastoma 12/2016
1	Central Nervous System Diseases (CNS Diseases) 10/2016
1	Brain Edema (Cerebral Edema) 09/2015
1	Cicatrix (Scar) 01/2015
1	Ganglion Cysts (Ganglion) 06/2013
1	Memory Disorders (Memory Loss) 01/2013
1	Pathologic Processes 01/2011
1	Neurologic Manifestations (Neurological Manifestations) 12/2007

Drug/Important Bio-Agent (IBA)

9	Sodium-Calcium ExchangerIBA 01/2020 - 11/2004
6	Protein Isoforms (Isoforms)IBA 06/2022 - 01/2011
5	Neuroprotective AgentsIBA 06/2022 - 01/2013
5	Proteins (Proteins, Gene)FDA Link 04/2016 - 11/2004
4	SodiumIBA 06/2022 - 03/2007
4	CalciumIBA 06/2022 - 03/2007
4	Histone Deacetylases (Histone Deacetylase)IBA 10/2020 - 01/2013
3	AntiportersIBA 06/2022 - 01/2013
3	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 01/2013
3	Oxygen (Dioxygen)IBA 11/2021 - 01/2013
3	MicroRNAs (MicroRNA)IBA 01/2021 - 10/2014
3	Histones (Histone)IBA 10/2020 - 01/2013
2	MetalsIBA 01/2021 - 01/2018
2	UbiquitinIBA 01/2020 - 04/2016
2	Ion Channels (Ion Channel)IBA 01/2020 - 01/2018
2	ResveratrolIBA 01/2018 - 01/2013
2	Sirtuin 1IBA 01/2018 - 01/2013
2	entinostat (MS 275)IBA 01/2018 - 01/2013
2	Pharmaceutical PreparationsIBA 01/2018 - 01/2015
2	Dihydrotachysterol (AT 10)IBA 08/2015 - 12/2007
1	CalpainIBA 06/2022
1	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2021
1	Transcription Factor MTF-1IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	Collagenases (Collagenase)FDA Link 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Ligases (Synthetase)IBA 12/2020
1	3' Untranslated Regions (3' UTR)IBA 12/2019
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2018
1	AMP-Activated Protein KinasesIBA 01/2018
1	ZincIBA 01/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018
1	IonsIBA 01/2018
1	IronIBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	Dinoprostone (PGE2)FDA Link 01/2018
1	CopperIBA 01/2018
1	Thimerosal (Thiomersal)IBA 12/2016
1	Adenosine Triphosphatases (ATPase)IBA 10/2016
1	K Cl- CotransportersIBA 10/2016
1	Sodium-Hydrogen ExchangersIBA 10/2016
1	UbiquitinsIBA 04/2016
1	Calbindin 2IBA 03/2016
1	Calcium-Binding ProteinsIBA 03/2016
1	Peptides (Polypeptides)IBA 09/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2015
1	5- amino- N- butyl- 2- (4- ethoxyphenoxy)- benzamide hydrochlorideIBA 08/2015
1	Hypoxia-Inducible Factor 1IBA 05/2015
1	RE1-silencing transcription factorIBA 05/2015
1	sodium-calcium exchanger 1IBA 10/2014
1	Hexamethonium (Hexamethonium Bromide)IBA 06/2013
1	NF-kappa B (NF-kB)IBA 01/2013
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2013
1	7- nitro- 5- phenyl- 1- (pyrrolidin- 1- ylmethyl)- 1H- benzo(e)(1,4)diazepin- 2(3H)- oneIBA 01/2013
1	EnzymesIBA 01/2013
1	Levetiracetam (Keppra)FDA LinkGeneric 01/2013
1	Acid Sensing Ion ChannelsIBA 01/2011
1	CationsIBA 01/2011
1	Protons (Proton)IBA 01/2011
1	OligodeoxyribonucleotidesIBA 02/2008
1	AntithrombinsIBA 12/2007
1	Thrombin FDA Link 12/2007
1	Proteinase-Activated ReceptorsIBA 12/2007
1	potassium-dependent sodium-calcium exchangerIBA 03/2007

Therapy/Procedure

2	Therapeutics 01/2021 - 01/2013
2	Ischemic Postconditioning 01/2021 - 01/2011
1	Intraventricular Infusions 12/2019
1	Denervation 12/2018